• Verapamil a calcium channel blocker

  2020-08-04

  

  Verapamil, a calcium channel blocker used clinically as a coronary vasodilator, was amongst the first compounds identified that could reverse MDR and potentiate the effects of MDR1 substrates such as vincristine [15], [16]. Verapamil, along with a number of other MDR1 blockers, have proved largely u

• During these processes meiotic recombination plays a critica

  2020-08-04

  

  During these processes, meiotic recombination plays a critical role by physically associating homologs and ensures accurate chromosome segregation. In addition, meiotic recombination redistributes genetic material between homologs, resulting in haplotype diversity among progeny, impacting ecological

• br Diacylglycerol kinases and the regulation of signaling

  2020-08-04

  

  Diacylglycerol kinases and the regulation of “signaling” DAG In contrast, DAG phosphorylation to PA by diacylglycerol kinases (DGKs) represents a quantitatively minor metabolic pathway, but is generally regarded as a main disposal pathway for “signaling” DAG. PA produced by DGKs is an intermediat

• br NADH and NADPH Turnover and the

  2020-08-04

  

  NADH and NADPH Turnover and the Putative Role of Alternative NAD(P)H Dehydrogenases Still very little is known about the metabolic function of external and internal alternative NADH:UQ oxidoreductases, and almost nothing is known about the mechanisms underlying their metabolic regulation, especia

• The re assortment of mutations to produce favorable combinat

  2020-08-03

  

  The re-assortment of mutations to produce favorable combinations that can undergo natural selection is a critical component of biological evolution. This process can be simulated by directed evolution, which has proved to be an effective strategy for improving or altering the activity of biomolecule

• As mentioned above the quality of the education received

  2020-08-03

  

  As mentioned above, the quality of the education received at a particular institution should be considered a primary driver of the potential success of the students in passing the CPA exam. Besides accreditation, another indicator of academic quality is the selectivity of an institution when determi

• Importantly there is marked inter individual variability in

  2020-08-03

  

  Importantly, there is marked inter-individual variability in the susceptibility to the effects of cannabis (Atakan et al., 2013). One possibility is that inter-individual differences in the impact of cannabis are explained by genetic variation. In this context, an extensively studied vulnerability g

• br Funding This study was supported by the

  2020-08-03

  

  Funding This study was supported by the Open Fund of Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research (Grant number: GXBMR201601), National Natural Science Foundation of China (Grant number: NSFC81560386), funds of Guangxi Zhuang Autonomous Region Health,

• br Materials and methods br

  2020-08-03

  

  Materials and methods Results Discussion Raghavan and colleagues described the synthesis and characterization of a compound, SCR7, that inhibited DNA ligase IV and blocked DNA ligase IV-dependent NHEJ in extracts and cell-based assays [11]. Furthermore, they reported that this Pentostatin m

• Herein the SNP and INDEL

  2020-08-01

  

  Herein, the SNP and INDEL variant effect prediction data presented by Wendt et al. [27] are expanded upon using the phased data of the 1000 Genomes Project [28]. Full-gene haplotypes of UGT2B7, ABCB1, OPRM1, and COMT were characterized in self-reported healthy individuals. When compared to CYP2D6-pr

• (-)-Bicuculline methobromide Recent studies have shown that

  2020-07-31

  

  Recent studies have shown that nuclear localization and the gene-regulatory function of SHP are enhanced by postprandial FGF19 signaling. In the liver, FGF19 mediates phosphorylation of SHP at Thr-55, which is critical for its interaction with RanBP2, a nuclear pore component and SUMO ligase that pr

• br The need for modified therapeutic proteins and why they

  2020-07-31

  

  The need for modified therapeutic proteins and why they need to last longer in the body Chemical and structural changes in therapeutic proteins are possible and are carried out frequently to accomplish pharmacological or clinical benefit. Such modifications are essential as the drug needs to pass

• COX enzymes have repeatedly been suggested as targets for

  2020-07-31

  

  COX enzymes have repeatedly been suggested as targets for adjunctive therapies in epilepsies (Kulkarni and Dhir, 2009, Takemiya et al., 2007, Potschka, 2010). We recently demonstrated that COX-2 inhibition can control P-glycoprotein expression, improve antiepileptic drug Rottlerin australia penetra

• Recombinant Leishmania antigens have been evaluated as

  2020-07-31

  

  Recombinant Leishmania antigens have been evaluated as new diagnostic tools for VL. Fonseca et al. (2014) showed that the recombinant C9 protein presented an accuracy of 0.79, with specificity and sensitivity values of 80% and 70%, respectively, for the serodiagnosis of human VL. Oliveira et al. (20

• Introduction Pain is frequently the

  2020-07-31

  

  Introduction Pain is frequently the first clinical symptom of head and neck carcinoma. Indeed, pain is the initial reason leading ∼70% of cancer patients to seek professional assistance (Lam & Schmidt, 2011; Rettig & D’Souza, 2015; Schmidt, 2014). Clinically, cancer-induced facial pain can be evoke

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