• br Hedgehog HH signaling plays an important

  2021-12-01

  

  Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells, tissue repair, and regeneration (, ). Three ligands, Indi

• Gli signaling pathways play critical

  2021-12-01

  

  Gli signaling pathways play critical roles in embryonic and postnatal lung development [22]. Many reports suggest that wound healing and fibrotic diseases involve activation of pathways used during development [23]. In the adult lung, Gli signaling activity measured by Gli1 expression is restricted

• At the end of experiments rats were

  2021-12-01

  

  At the end of experiments rats were injected high dose of sodium pentobarbital (90mg/kg) and the rat’s head was cut and frozen in −20°C for 20min with the injecting tube in situ before section. The location of the tip of the injecting tube was verified and all the tips of the injecting tube were in

• In conclusion our work demonstrates for the first time that

  2021-12-01

  

  In conclusion, our work demonstrates for the first time that (i) SA-β-gal activity is abundantly present in the gamete cells, such as oocytes and eggs, (ii) the enzyme resides in different cell compartments, (iii) SA-β-gal activity is localized predominantly in acidic endosomal yolk platelets, and (

• H O induced astrocyte ATP

  2021-12-01

  

  H2O2 induced astrocyte ATP release through lysosome exocytosis. The LDH assay and electric microscope results indicated that the increase of extracellular ATP concentration was not due to the cell rupture, but the alternations in cell activities. In addition, when lysosome exocytosis was blocked by

• Newly identified evidence has put immune checkpoint inhibito

  2021-12-01

  

  Newly identified evidence has put immune checkpoint inhibitors into the spotlight. However, even though they have been reported to achieve optimistic outcomes [67], there is still a provocative question about their limitations [68]. The solid evidence above has provided us with translational values

• br Materials and methods br Results br Discussion Myocardium

  2021-12-01

  

  Materials and methods Results Discussion Myocardium reperfusion injury contributes almost half of myocardial infarct size in myocardial infarction patients, and infarct size is closely correlated with the probability of developing N-3-oxo-dodecanoyl-L-Homoserine lactone failure [1]. Despite

• In summary P P macrocyclization

  2021-12-01

  

  In summary, P2-P4 macrocyclization proved to be an effective strategy to drive activity in this series of HCV NS3 protease inhibitors while microsomal stability was enhanced by the introduction of steric bulk along the tether. This modification augmented the previously-described tactic of improving

• The crystal structures of plant class

  2021-12-01

  

  The crystal structures of plant class ADH3/GSNOR from Arabidopsis thaliana (AtGSNOR) and Solanum lycopersicum cv. Amateur (SlGSNOR) with bound substrates and cofactors revealed important differences between plant and human enzyme, namely within the substrate-binding pocket. GSNOR are unusually homod

• While a role for YAP

  2021-12-01

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these T7 High Yield RNA are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent ma

• In this study we find that

  2021-11-30

  

  In this study, we find that DH-CBD induces analgesic effects on inflammatory but not acute pain and the Mevastatin australia level of spinal α1 GlyRs increased after CFA paw injection. These results suggest that GlyR α1 is only involved in chronic pain. A possible explanation is that once the expre

• allow to br Materials and methods br Results

  2021-11-30

  

  Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino allow to residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other additional ami

• Interestingly transgenic mice that constitutively express

  2021-11-30

  

  Interestingly, transgenic mice that constitutively express active FXR in the intestine (iVP16FXR) are protected from chemically-induced and genetically-induced cholestasis. This protective effect is attributed to the induction of intestinal FGF15 and repression of hepatic Cyp7a1 expression, downregu

• Macroautophagy hereafter referred to as autophagy depends on

  2021-11-30

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• In analyzed alleles in this

  2021-11-30

  

  In 3/11 analyzed IGF-1, human recombinant in this study, the c.472C>T missense variant was detected. This variant was previously reported in Malaysian, French, Indian and Pakistani patients (Bhai et al., 2018; Ijaz et al., 2017; Lebigot et al., 2015; Moey et al., 2018; Ngu et al., 2014) who were ho

14116 records 501/942 page Previous Next First page 上5页 501502503504505 下5页 Last page