• Cisplatin Another major problem leading to implant failures

  2022-10-17

  

  Another major problem leading to implant failures is post-implant infections, majorly due to bacteria adhesion [13,36,37]. A significant decrease in bacterial counts (~65–90%) has been observed in HA and/or CNT-based composites reinforced with 2.5–10 wt% nano Ag [13,38], thus, drawing the conclusion

• HMGN proteins are subject to extensive post translational mo

  2022-10-17

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to tandospirone and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]). Th

• The reactions and the control mechanisms described are

  2022-10-14

  

  The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of ck2 inhibitor cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of

• The finding that OCT is expressed in the

  2022-10-14

  

  The finding that OCT3 is expressed in the nucleus accumbens (Gasser et al., 2009) suggests that inhibition of this transporter may underlie previously described effects of glucocorticoids on extracellular DA concentrations and indicates that DA clearance in this region is not mediated exclusively by

• br Discussion With recently improved understanding of the ro

  2022-10-14

  

  Discussion With recently improved understanding of the role of βARK1 in the progression of HF and as a potential therapeutic target in HF, we explored the relationship between plasma βARK1, as a marker of chronic sympathetic overactivation, and physical symptoms in HF. Our main findings were 1) e

• It is important to note that stable amnesia is

  2022-10-14

  

  It is important to note that stable amnesia is, apparently, a general biological phenomenon and can be found in different animal species. In studies on rats, it was found that if reconsolidation of conditioned olfactory aversion memory was impaired by the antagonist of NMDA glutamate receptors, amne

• br Introduction Adenosine deaminase ADA which can catalyze

  2022-10-14

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• The extent to which GPCR

  2022-10-14

  

  The extent to which GPCR oligomerization is a regulated process still remains unclear. Reported effects of ligands on both GPCR homo- and heteromers are highly variable and depend on GPCR subtypes and the specific ligand used. According to our data, chronic treatment of mice with both paroxetine or

• br Acknowledgements DHA was funded by a research grant

  2022-10-14

  

  Acknowledgements DHA was funded by a research grant from Viamet and IMB and DHA were/are consultants for Viamet/Innocrin. DHA also supported by NIH P51-OD011106. Introduction Congenital adrenal hyperplasia resulting from 17alpha-hydroxylase and 17,20-lyase deficiency (17OHD) is a rare autosom

• Matsuzaki et al attempted fertility therapy

  2022-10-14

  

  Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a monensin heterozygote for delF53/54 and the missense mutation H373L, which has cycle supports this theory. Oocyte dysfunction with decreased granulosa cell activity might also contrib

• Further analysis sought to understand the mechanism associat

  2022-10-14

  

  Further analysis sought to understand the mechanism associated with the autotaxin-mediated increase of miR-489-3p in circulation. Based upon sequence complementarity, DIANA TarBase predicted miR-489-3p targets MAPK2K1, or MEK1, an oncogene widely dysregulated in cancer (Fig. 4A). To test this relati

• On the contrary evidence also suggests that autophagy plays

  2022-10-14

  

  On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer Selumetinib require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend providing all th

• We also showed that steatosis

  2022-10-13

  

  We also showed that steatosis induced an additional increase of ASK1 activation that was associated to the exacerbation of hepatocyte and liver damage and was unrelated to ER stress. Indeed, several settings, also different to ER stress, can induce ASK1 activation and many of them involve oxidative

• Hypoxia of the adipose tissue

  2022-10-13

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• The most common adverse effects were ARIA which

  2022-10-13

  

  The most common adverse effects were ARIA, which occurred at higher levels than in any previous anti-Aβ mAb study. ARIA-E was observed at some point during the trial in no participants in the placebo group compared with 1 (3%), 2 (6%), 11 (37%), and 13 (41%) participants receiving 1, 3, 6, and 10 mg

14485 records 357/966 page Previous Next First page 上5页 356357358359360 下5页 Last page