• br Material and methods br Results

  2023-01-29

  

  Material and methods Results Discussion Neurotransmitters pathways within vertebrates, including fish, are well conserved (Kreke and Dietrich, 2008, Valenti et al., 2012). Therefore psycopharmaceuticals that are design to act on these pathways in mammals, will possibly interact with the sam

• br Thymic expression of AChR Both

  2023-01-29

  

  Thymic expression of AChR Both linear unfolded epitopes of AChR subunits and the intact AChR are avidly expressed in thymus, particularly by thymic epithelial cells and myoid cells [17], [18], [19]. AChR-antibody positive MG patients often show thymic hyperplasia, characterized by lymphoid follic

• br ATX LPA pathway in animal models of rheumatoid arthritis

  2023-01-29

  

  ATX–LPA pathway in animal models of rheumatoid arthritis Several animal models have been used to characterize the mechanisms involved in the pathogenesis of arthritis and to test new therapeutic strategies. The collagen-induced arthritis (CIA) model (Courtenay et al., 1980, Luross and Williams, 2

• Investigating these possibilities will illuminate whether ce

  2023-01-29

  

  Investigating these possibilities will illuminate whether CCK Octapeptide, non-sulfated receptor possess mechanisms to differentially detect ACLY-generated versus ACSS2-generated acetyl-CoA as well as define the functional relationship between histone acetylation levels and cellular functions and p

• Because R gene is positively

  2023-01-29

  

  Because 5α-R2 gene is positively regulated by T and in the prostate gland (Torres et al., 2003), and our BPA-treated rats showed decreased circulating T and probably intraprostatic androgen levels, it might be responsible for the decrease of 5α-R2 expression. However, in a previous work using castra

• Among steroid saponins ginsenosides are the active component

  2023-01-29

  

  Among steroid saponins, ginsenosides are the active components of ginseng, a well-known chinese medicinal plant. More than hundreds of different ginsenosides have been isolated from ginseng and have shown in the past to be membrane active substances and to influence the membrane by modulating lipid

• br Conflicts of interest br Contributors

  2023-01-29

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• In order to further explore whether the

  2023-01-29

  

  In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 H-Lys(Ac)-OH.HCl is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activity. A la

• br Methods The study population

  2023-01-28

  

  Methods The study population included 64 neuropathologically confirmed AD patients (6 male, 58 female) that were recruited into a longitudinal follow-up study of patients with dementia of Alzheimer’s type from the geriatric department of Harjula Hospital in Kuopio, Finland. At baseline the patien

• Carbamazepine We next developed a system

  2023-01-28

  

  We next developed a system for staging severity. Our guiding principles were the following. Two types of information about the research participant are staged independently from each other: (1) grading disease severity using biomarkers and (2) grading the severity of cognitive impairment. Measures u

• As one of emerging high throughout methods metabolomics dete

  2023-01-28

  

  As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica

• br Parkinson s Disease and the immune system Parkinson s

  2023-01-28

  

  Parkinson’s Disease and the immune system Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s, which affects 10 million people globally and is characterized by rigidity, bradykinesia, tremors, and gait instability (O’sullivan et al., 2007). The patholo

• Recent studies demonstrated that AHR has an important

  2023-01-28

  

  Recent studies demonstrated that AHR has an important role in the interplay between cancer metabolism and tumor-specific immunity. Tryptophan catabolism is increasingly recognized as a metabolic pathway that promotes tumorigenesis through its role in immune suppression [75]. The rate-limiting enzyme

• The biology of the A BR is

  2023-01-28

  

  The biology of the A2BR is complex and needs to be considered contextually as the expression and effect of receptor engagement varies according to time post hypoxic injury, cell type and downstream signaling pathway. For example, A2BR expression is dynamic - low under basal and increasing under isch

• A key step in the ADAR reaction is the formation

  2023-01-28

  

  A key step in the ADAR reaction is the formation of the adenosine covalent hydrate with a tetrahedral center at C6. The nucleoside analog 8-azanebularine (box in Fig. 6), with its relatively high propensity to form a covalent hydrate, is useful as an adenosine replacement in ADAR2 substrates to trap

14539 records 333/970 page Previous Next First page 上5页 331332333334335 下5页 Last page