• Finally impaired endothelial integrity culminates

  2023-10-09

  

  Finally, impaired endothelial integrity culminates in an increased plasma protein concentration in the interstitial space, and thus accumulation of fluid in the ECM, favoring the swelling of the face and limbs [2] mainly. Concurrently with this systemic change, there is intense activation of coagula

• The RAS may have different functions depending on whether we

  2023-10-09

  

  The RAS may have different functions depending on whether we consider the circulatory component or the different local tissue systems (including brain) well described previously [29]. The cardiovascular control and hydroelectrolytic balance (among other functions), are largely the result of the infl

• Based on our findings in this

  2023-10-09

  

  Based on our findings in this work as well as the previous published data in the experimental mice model of RSV infection, we suggest that modulation of 12/15 LOX expression and/or blocking of LOX products such as 12(S)-HETE may represent potential pharmacological approaches to prevent or treat vira

• Nutritional factors affecting ASD have also recently receive

  2023-10-08

  

  Nutritional factors affecting ASD have also recently received attention. An increase in postsynaptic zinc (Zn) level induced by clioquinol (a Zn chelator and ionophore), and the subsequent activation of NMDA receptors through the tyrosine kinase Src, rescued social interaction in Shank2−/− mice (Lee

• br Actin at presynapses br Conclusion

  2023-10-08

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal Hydroxyurea is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these

• br COX and LOX in post mortem

  2023-10-08

  

  COX and 5-LOX in post-mortem AD brain Minghetti (2004) reviewed the findings on COX-2 mRNA levels in AD brains, pointing out that the available evidence demonstrated either decreased or increased levels, possibly because of the short half-life of COX-2 transcripts or individual variability. Histo

• We found that several anticancer

  2023-10-08

  

  We found that several anticancer drugs inhibit 5-HT3 Benazepril HCl current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used fre

• Given the profound expression of HT A

  2023-10-08

  

  Given the profound AMG232 of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversible post

• Escitalopram Oxalate Normally the activity of the lyase incr

  2023-10-08

  

  Normally, the activity of the 17,20-lyase increases with the onset of adrenarche [7], [8], [15]. Adrenarche has previously been perceived as a relatively sudden event, occurring physiologically between 6 and 8years of age. However, results from our laboratory clearly indicated that adrenarche is a c

• br Results br Discussion br Conclusion

  2023-10-08

  

  Results Discussion Conclusion The flux of glucose into cytosolic short chain acyl-CoAs was maintained in pure beta parecoxib in the presence of inhibition of ATP citrate lyase with hydroxycitrate and also in a cell line with >90% ATP citrate lyase knockdown suggesting that a pathway other

• br Mechanisms of homeostasis At

  2023-10-08

  

  Mechanisms of homeostasis At face value, homeostatic mechanisms may seem like nothing more than a simple balance between opposing forces; however, the ability of Mec1/Tel1 to each orchestrate both negative and positive regulation greatly complicates the system under consideration and argues again

• AR Vs are truncated AR proteins lacking

  2023-10-08

  

  AR-Vs are truncated AR proteins lacking the AR ligand-binding domain (AR-LBD) [6]. While AR-Vs have frequently been detected in CRPC, their expression and functional role in benign prostate tissues and primary prostate cancers is not readily apparent. Structural rearrangements in the AR gene and alt

• br Results br Discussion Using primarily

  2023-10-08

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• and LO are members of

  2023-10-08

  

  5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic d-cycloserine sale into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation

• br Discussion Elevated blood BCAA levels are

  2023-10-08

  

  Discussion Elevated blood BCAA levels are a common feature of a developed pathophysiological state characterized by obesity and IR [4]. It has been suggested that this profile is part of a panel of biomarkers able to predict the onset of more severe complications like diabetes in humans [14]. In

14437 records 259/963 page Previous Next First page 上5页 256257258259260 下5页 Last page