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The functions of HMGN protein are modulated by various post
2024-06-17
The functions of HMGN1 protein are modulated by various post-translational modifications, including phosphorylation , , , acetylation , and glycosylation . Phosphorylation in HMGN1 may influence its binding affinity to DNA or nucleosome-associated proteins and affect the sub-cellular localization an
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Although many factors influence the
2024-06-17
Although many factors influence the effects of medications, during recent years it has become evident that genetic factors could explain the differences between individuals in drug response. These differences are due to variants in genes encoding drug targets [8]. The challenge for pharmacogenetics
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br Introduction Breast cancer is
2024-06-17
Introduction Breast cancer is the second most lethal cancer among women, accounting for approximately 40,000 deaths in the United States in 2015 [1]. The prognosis of breast cancer has improved significantly with the identification of immunohistochemical subtypes that predict response to therapy
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Introduction Alzheimer s disease AD is a
2024-06-17
Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prote
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Perhaps the discovery of this linkage
2024-06-14
Perhaps the discovery of this linkage has served to catapult much of the work on ABCA1, leaving its family member in need of a relationship with a defined human pathology. In this regard, there is by now a quite mature literature that suggests that ABCA2 may have been overlooked in terms of its impo
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br Transparency document br Introduction G protein coupled
2024-06-14
Transparency document Introduction G protein-coupled receptors (GPCRs) comprise a diverse family of seven transmembrane domain-containing receptors represented by over 800 genes in humans. GPCRs respond to a range of stimuli, including peptides, hormones, growth factors, lipids, odorants, and
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br Materials and methods br Discussion Few studies have exam
2024-06-14
Materials and methods Discussion Few studies have examined peripheral PACAP levels in migraineurs, and no reports have described PACAP levels in blood samples from patients with CM. Here, we demonstrated that plasma PACAP concentrations were lower in patients with interictal migraine (in both
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Mast cells Mast cells are immune
2024-06-14
Mast cells. Mast plk1 inhibitor are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination [75]. Moreover,
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Tension within the network could be explained
2024-06-14
Tension within the network could be explained by two potential mechanisms: the more classical contractility that is dependent on motor proteins that are pulling AL 8810 filaments towards each other [10]; or contractility that is caused by disassembly of a crosslinked network of actin filaments [2].
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The AAP s policy statement on childhood
2024-06-14
The AAP’s policy statement on childhood adversities is a call to the pediatric WAY-262611 australia to apply the knowledge toward developmental screening in clinical practice. It is a movement to increase education around childhood adversity as a public health crisis and to build trauma-informed ca
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A promising target that is involved in the
2024-06-14
A promising target that is involved in the biosynthesis of the precursor LTA4 is the 5-LO-activating protein (FLAP), which in vivo is seemingly indispensable for LT formation [8], [9]. FLAP, a member of the MAPEG family (membrane-associated proteins in eicosanoid and glutathione metabolism), is an i
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We found that several anticancer drugs inhibit HT receptor
2024-06-14
We found that several anticancer drugs inhibit 5-HT3 BMH-21 current in vitro. Several studies have suggested that 5-HT3 receptor antagonists have anti-mitogenic and apoptotic effects on colorectal and breast cancer cell lines (Ataee et al., 2010, Hejazi et al., 2015). Irinotecan is used frequently
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br Regulation of V ATPase assembly in response to changes
2024-06-14
Regulation of V-ATPase assembly in response to changes in amino p16 levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and autophagy. Act
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flumethasone As cytosolic acetyl CoA levels in hepatocytes d
2024-06-14
As cytosolic acetyl-CoA levels in hepatocytes descend, cellular production and concentration of cholesterol go down, a change that is known to be sensed by the Sterol response element binding protein (SREBP)/Cleavage-Activating Protein system, leading to SREBP escort to the Golgi apparatus, cleavage
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We also show that in
2024-06-14
We also show that in both ATM proficient and deficient/mutant pilocarpine hcl the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair pathway [
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